Immunohistochemical Evalution of Endoglin (CD 105) as Angiogenic Endothelial Marker of Squamous Cell Carcinoma in Dogs

Back ground: Angiogenesis is the process of using existent vascular bed to form new blood vessels. Neoangiogenesis one hallmarks cancer for tumour progression and metastasis. Microvessel density (MVD) a powerful prognostic tool in oncology assessing vasculature. Endoglin (CD 105) specific marker activated endothelium. The present research intends investigate metastatic potential immunohistochemical expression canine squamous cell carcinoma (SCC). Method: Totally, 15 SCC were collected from Veterinary Clinical Complex, Tirunelveli during year period. tumours histopathologically identified as different grades. Immunohistochemically analysed with Peritumoural microvessel intratumourl (PTMVD ITMVD) calculated “hot spot method”. Result: All cases positive CD 105 strongly stained both peritumoural intratumoural Among types SCC, Grade III had highest values density. study concluded that grades have MVD within cases, thereby reflecting behaviour neoplasms directly. best endothelial markers determine because it aids assess plays significant role estimation overall survival period after surgery.